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Jeffrey D. Laskin, Ph.D.


Jeffrey Laskin, Ph.D.

Professor & Chief, Division of Toxicology
Environmental and Occupational Medicine

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ


                                        

Dr. Jeffrey D. Laskin is a Professor and Chief of the Division of Toxicology in the Department of Environmental and Occupational Medicine at UMDNJ-Robert Wood Johnson Medical School (RWJMS).   He is director of the Toxicology Division at the Environmental and Occupational Health Sciences Institute (EOHSI), a joint program of Rutgers University and UMDNJ and is Deputy Director of the Joint Graduate Program in Toxicology at UMDNJ and Rutgers University.  He is Director of the UMDNJ/Rutgers University CounterACT Research Center of Excellence, a major White House initiated national security priority to expedite research on the most promising scientific discoveries that would lead to improved medical countermeasures to protect Americans against a chemical, biological, radiological, or nuclear (CBRN) attack.  He is a member of the NJ Department of Homeland Security Preparedness College and is a founding member of the Executive Committee of the University Center for Disaster Preparedness and Emergency Response of RWJMS-UMDNJ, Rutgers University, and Robert Wood Johnson University Hospital.  In 2007 he was an invited to presenter at NATO’s initiative on “Defense Against the Effects of Chemical Hazards’ in Edinburgh, Scotland.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY.  He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the UMDNJ-Robert Wood Johnson Medical School.  Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing.  He is a member of the Graduate School at Rutgers University, the Pharmacology graduate program at UMDNJ-Robert Wood Johnson Medical School and the Cancer Institute of New Jersey. Dr. Laskin also serves as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as an editor on over 20 journals that deal with pharmacology, toxicology and cancer research.  With over 150 peer-reviewed publications, a book, numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology.  His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 25 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.


Selected Publications:

Jan, Y. H., D. E. Heck, et al. (2014). "Acetaminophen reactive intermediates target hepatic thioredoxin reductase." Chem Res Toxicol 27(5): 882-894.
Jan, Y. H., D. E. Heck, et al. (2014). "Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling." Chem Res Toxicol 27(1): 61-75.
Joseph, L. B., D. E. Heck, et al. (2014). "Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard." Exp Mol Pathol 96(3): 316-327.
Malaviya, R., J. D. Laskin, et al. (2014). "Oxidative stress-induced autophagy: role in pulmonary toxicity." Toxicol Appl Pharmacol 275(2): 145-151.
Zheng, R., A. C. Dragomir, et al. (2014). "Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats." Toxicol Appl Pharmacol.
Zheng, R., D. E. Heck, et al. (2014). "Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid." Free Radic Biol Med 67: 1-9.
Zheng, R., D. E. Heck, et al. (2014). "Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product." Toxicol Appl Pharmacol 275(2): 113-121.
Chang, Y. C., J. D. Wang, et al. (2013). "Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model." Toxicol Appl Pharmacol 268(2): 178-187.
Connor, A. J., L. C. Chen, et al. (2013). "Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4." Exp Mol Pathol 94(1): 216-227.
Groves, A. M., A. J. Gow, et al. (2013). "Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation." Am J Physiol Lung Cell Mol Physiol 305(8): L555-568.
Liu, Y., C. R. Gardner, et al. (2013). "Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli." Exp Mol Pathol 94(1): 160-167.
Sunil, V. R., K. N. Vayas, et al. (2013). "Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics." Toxicol Sci 133(2): 309-319.
Yang, S., Y. H. Jan, et al. (2013). "Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells." J Biol Chem 288(26): 19221-19237.
Zheng, R., I. Po, et al. (2013). "The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard." Toxicol Appl Pharmacol 272(2): 345-355.
Connor, A. J., J. D. Laskin, et al. (2012). "Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4." Exp Mol Pathol 92(2): 229-235.
Deshmukh, M., H. L. Kutscher, et al. (2012). "Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates." J Control Release 164(1): 65-73.
Dragomir, A. C., R. Sun, et al. (2012). "Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication." J Immunol 189(12): 5934-5941.
Dragomir, A. C., R. Sun, et al. (2012). "Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production." Toxicol Sci 127(2): 609-619.
Gardner, C. R., P. Hankey, et al. (2012). "Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase." Toxicol Appl Pharmacol 262(2): 139-148.
Gardner, C. R., V. Mishin, et al. (2012). "Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole." Toxicol Sci 125(2): 607-612.
Groves, A. M., A. J. Gow, et al. (2012). "Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation." Am J Respir Cell Mol Biol 47(6): 776-783.
Malaviya, R., A. Venosa, et al. (2012). "Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor." Toxicol Appl Pharmacol 265(3): 279-291.
Sunil, V. R., K. Patel-Vayas, et al. (2012). "Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress." Toxicol Appl Pharmacol 263(2): 195-202.
Sunil, V. R., J. Shen, et al. (2012). "Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning." Toxicol Appl Pharmacol 261(1): 22-30.
Trabaris, M., J. D. Laskin, et al. (2012). "Effects of temperature, surfactants and skin location on the dermal penetration of haloacetonitriles and chloral hydrate." J Expo Sci Environ Epidemiol 22(4): 393-397.
Trabaris, M., J. D. Laskin, et al. (2012). "Percutaneous absorption of haloacetonitriles and chloral hydrate and simulated human exposures." J Appl Toxicol 32(6): 387-394.
Young, S. C., K. M. Fabio, et al. (2012). "Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation." J Appl Toxicol 32(2): 135-141.
Black, A. T., M. K. Gordon, et al. (2011). "UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells." Biochem Pharmacol 81(7): 873-880.
Black, A. T., P. J. Hayden, et al. (2011). "Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide." Toxicol Appl Pharmacol 253(2): 112-120.
Dragomir, A. C., J. D. Laskin, et al. (2011). "Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1." Toxicol Appl Pharmacol 253(3): 170-177.
Fussell, K. C., R. G. Udasin, et al. (2011). "Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase." Free Radic Biol Med 50(7): 874-882.
Fussell, K. C., R. G. Udasin, et al. (2011). "Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells." Carcinogenesis 32(8): 1285-1293.
Joseph, L. B., D. R. Gerecke, et al. (2011). "Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage." Exp Mol Pathol 91(2): 515-527.
Laskin, D. L., V. R. Sunil, et al. (2011). "Macrophages and tissue injury: agents of defense or destruction?" Annu Rev Pharmacol Toxicol 51: 267-288.
Sunil, V. R., K. Patel-Vayas, et al. (2011). "Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide." Toxicol Appl Pharmacol 250(3): 245-255.
Sunil, V. R., K. J. Patel, et al. (2011). "Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard." Toxicol Appl Pharmacol 250(1): 10-18.
Weinberger, B., J. D. Laskin, et al. (2011). "Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity." Pulm Pharmacol Ther 24(1): 92-99.
Black, A. T., P. J. Hayden, et al. (2010). "Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide." Toxicol Appl Pharmacol 249(2): 178-187.
Black, A. T., L. B. Joseph, et al. (2010). "Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide." Toxicol Appl Pharmacol 245(3): 352-360.
Gardner, C. R., J. P. Gray, et al. (2010). "Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity." Toxicol Appl Pharmacol 245(1): 36-46.
Gray, J. P., V. Mishin, et al. (2010). "Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species." Toxicol Appl Pharmacol 247(2): 76-82.
Heck, D. E., M. Shakarjian, et al. (2010). "Mechanisms of oxidant generation by catalase." Ann N Y Acad Sci 1203: 120-125.
Jan, Y. H., D. E. Heck, et al. (2010). "Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells." Chem Res Toxicol 23(6): 1045-1053.
Laskin, D. L., L. Chen, et al. (2010). "Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia." J Leukoc Biol 88(2): 373-382.
Laskin, D. L., V. R. Sunil, et al. (2010). "Macrophages, reactive nitrogen species, and lung injury." Ann N Y Acad Sci 1203: 60-65.
Laskin, J. D., A. T. Black, et al. (2010). "Oxidants and antioxidants in sulfur mustard-induced injury." Ann N Y Acad Sci 1203: 92-100.
Malaviya, R., V. R. Sunil, et al. (2010). "Inflammatory effects of inhaled sulfur mustard in rat lung." Toxicol Appl Pharmacol 248(2): 89-99.
Mishin, V., J. P. Gray, et al. (2010). "Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes." Free Radic Biol Med 48(11): 1485-1491.
Shakarjian, M. P., D. E. Heck, et al. (2010). "Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure." Toxicol Sci 114(1): 5-19.
Vetrano, A. M., D. L. Laskin, et al. (2010). "Inflammatory effects of phthalates in neonatal neutrophils." Pediatr Res 68(2): 134-139.
Wang, Y., J. P. Gray, et al. (2010). "Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity." Mol Cancer Ther 9(6): 1852-1863.
Young, S., K. Fabio, et al. (2010). "Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction." Bioorg Med Chem Lett 20(9): 2987-2990.
Sunil, V. R., K. J. Patel, et al. (2009). "Pulmonary effects of inhaled diesel exhaust in aged mice." Toxicol Appl Pharmacol 241(3): 283-293.
Black, A. T., J. P. Gray, et al. (2008). "Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes." Carcinogenesis 29(1): 219-225.
Black, A. T., J. P. Gray, et al. (2008). "Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat." Toxicol Appl Pharmacol 231(3): 384-392.
Black, A. T., J. P. Gray, et al. (2008). "UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes." Toxicol Appl Pharmacol 232(1): 14-24.
Chen, L. C., J. D. Laskin, et al. (2008). "Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia." Exp Mol Pathol 84(2): 145-155.
Fakhrzadeh, L., J. D. Laskin, et al. (2008). "Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation." Toxicol Appl Pharmacol 227(3): 380-389.
Wang, Y., J. P. Gray, et al. (2008). "Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity." Free Radic Biol Med 44(6): 1169-1179.
Weinberger, B., C. Quizon, et al. (2008). "Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4." Pediatr Res 64(4): 393-398.